MBL2 Mouse anti-Human, Clone: 3E7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140145
MA1-40145 detects MBL from human samples. The MA1-40145 immunogen is Mannose Binding Lectin (MBL). MA1-40145 has been successfully used in flow cytometry, Western blot, ELISA, Functional Assays, and immunohistochemistry (frozen) applications. Negative control: Nonimmune normal serum or TBS. Endotoxin <24 EU/mg.Mannose Binding Lectin (MBL) also called mannose- or man-binding protein (MBP) is a member of the group of collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBLMASP pathway (better known as the lectin pathway) is antibody and C1q–independent. MBL exhibits complementdependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.
|PBS with 0.1% BSA and no preservative|
|ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)|
|Serum isolated human RaRF|
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