LC3B Rabbit anti-Human, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA118293
PA1-18293 detects MAP1LC3 B from human and rat samples. PA1-18293 has been successfully used in immunohistochemistry, immunofluorescence, and Western blot procedures. The PA1-18293 immunogen is a synthetic peptide corresponding to the N-terminal residues of human MAP1LC3 B, conjugated to Blue Carrier Protein. The sequence is 100% conserved in mouse and rat. Reconstitute with 100 µL of distilled water.LC3B (Autophagy Marker Light Chain 3B, MAP1A/MAP1B LC3 B) in humans, is encoded by the gene MAP1LC3B (Microtubule-associated proteins 1A/1B light chain 3B). LC3B is associated with microtubule assembly and important is in neurogenesis. Recent studies indicate that LC3B plays a vital role in autophagy, a process that involves the bulk degradation of cytoplasmic component. Three human LC3 isoforms undergo post-translational modifications during autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). LC3B is a microtubule-associated protein that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3B may play a role in processes involving cancer, aging, metabolic and neurodegenerative disorders and cardiovascular/pulmonary diseases.
|whole serum with no preservative|
|Microtubule-associated proteins 1A/1B light chain 3B, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1A/1B light chain 3 B|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|Synthetic peptide corresponding to the N-terminal residues of human MAP1LC3 B conguate to Blue Carrier Protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
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