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mitogen-activated protein kinase kinase kinase 3, Mouse, Polyclonal Antibody, Abnova™
Mouse polyclonal antibody raised against a full-length human MAP3K3 protein.
Supplier: Abnova Corporation H00004215B01
Description
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Sequence: MNEANVMLPYSGKEEPVLPVAMTLPLPGRGPRCGTAATEGGSSFVNAVVSVLQVGVTLMLYPVSKLETVCALWALSTPALGLGLGCIEKSSpecifications
mitogen-activated protein kinase kinase kinase 3 | |
Polyclonal | |
Mouse polyclonal antibody raised against a full-length human MAP3K3 protein. | |
MAP3K3 | |
MAPKKK3/MEKK3 | |
Mouse | |
50 μL | |
Kinases | |
Primary | |
Human | |
Serum |
Western Blot | |
Unconjugated | |
No additive | |
BC010464 | |
MAP3K3 | |
MAP3K3 (AAH10464, 1 a.a. ∼ 90 a.a) full-length human protein. | |
RUO | |
Yes | |
4215 | |
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
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