mitogen-activated protein kinase kinase kinase 3, Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a full-length human MAP3K3 protein.

Manufacturer:  Abnova Corporation H00004215B01

Catalog No. 89-005-749

Description

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

Sequence: MNEANVMLPYSGKEEPVLPVAMTLPLPGRGPRCGTAATEGGSSFVNAVVSVLQVGVTLMLYPVSKLETVCALWALSTPALGLGLGCIEKS

Specifications

• Antigen: mitogen-activated protein kinase kinase kinase 3
• Conjugate: Unconjugated
• Formulation: No additive
• Gene Accession No.: BC010464
• Gene Alias: MAPKKK3|MEKK3
• Host Species: Mouse
• Quantity: 50 uL
• Research Discipline: Kinases
• Whole Molecule: Y
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Western Blot
• Description: Mouse polyclonal antibody raised against a full-length human MAP3K3 protein.
• Gene: MAP3K3
• Format: Serum
• Gene Symbols: MAP3K3
• Immunogen: MAP3K3 (AAH10464, 1 a.a. ~ 90 a.a) full-length human protein.
• Regulatory Status: RUO
• Storage Requirements: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Primary or Secondary: Primary
• Gene ID (Entrez): 4215