TPL2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527765
PA5-27765 targets MAP3K8 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-27765 immunogen is recombit fragment corresponding to a region within amino acids 223 and 467 of Human MAP3K8. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity.
|Recombit fragment corresponding to a region within amino acids 223 and 467 of Human MAP3K8|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT, Ewing sarcoma transformant, cot (cancer Osaka thyroid) oncogene, proto-oncogene c-Cot, proto-oncogene serine/threoine protein kinase, tumor progression locus 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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