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MAPKAPK-2 Mouse, Unlabeled, Clone: P24-694, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 562469

Catalog No. BDB562469


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Description

Description

The P24-694 monoclonal antibody specifically binds to the phosphorylated T334 site (pT334) of MAPKAPK-2. MAPKAPK-2 is a serine/threonine protein kinase. This ∽49 kDa member of the MAPKAPK family of protein kinases is also known as mitogen-activated protein kinase-activated protein kinase 2. MAPKAPK-2 is phosphorylated and activated by p38 MAP kinase in response to stress, cytokines and chemokines. MAPKAPK-2 is phosphorylated on multiple sites including Thr222, Ser272 and Thr334. Phosphorylation of any two of these three amino acid residues seems to be required for the activation of this kinase thatserves multiple cellular functions. Phosphorylation of Thr334 was reported to be essential for nuclear export of the heterodimer formed between p38 MAPK and MAPKAPK-2. Mice deficient in MAPKAPK-2 have been shown to be protected from ischemic injury. MAPKAPK-2 is also reported to serve as a cell cycle checkpoint kinase in response to UV irradiation. The heat shock protein, HSP27 was shown to be one of the major substrates of MAPK and MAPKAPK-2.

Specifications

Specifications

MAPKAPK-2
P24-694
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse
IgG1, κ
RUO
Primary
Human, Murine
Western Blot
0.5mg/mL
MAP kinase-activated protein kinase 2, MAPKAP kinase 2; MK2; MAPK2
Affinity Purified
Phosphorylated human MAPKAPK-2 peptide
0.1mg
Store undiluted at 4°C
Monoclonal
SDS
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