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MATN3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520726

Catalog No. PIPA520726


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Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20726 can be used with blocking peptide PEP-0840.

Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
Specifications

Specifications

MATN3
Polyclonal
Unconjugated
MATN3
Liquid
MATN3
A 13 amino acid peptide from near the carboxy terminus of human MATN3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O15232, O35701
DIPOA, EDM5, HOA, OADIP, OS2; matrilin-3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
17182, 313954, 4148
Documents
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