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MBD2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528277

Catalog No. PIPA528277


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Description

Description

PA5-28277 targets MBD2 in WB applications and shows reactivity with Human samples. The PA5-28277 immunogen is recombit fragment corresponding to a region within amino acids 123 and 349 of Human MBD2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Specifications

Specifications

MBD2
Polyclonal
Unconjugated
MBD2
Liquid
MBD2
Recombit fragment corresponding to a region within amino acids 123 and 349 of Human MBD2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
0.48 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q9UBB5
DMTase, NY-CO-41, demethylase, methyl-CpG-binding domain protein 2
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
8932
Documents
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