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MBD2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511196

Catalog No. PIPA511196

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.
Specifications

Specifications

MBD2
Polyclonal
PBS with 0.09% sodium azide
Q9UBB5, Q9Z2E1
MBD2
KLH conjugated synthetic peptide between 120-151 amino acids from the N-terminal region of human MBD2
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
Unconjugated
MBD2
Liquid
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
17191, 8932
Documents
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