CD146 Mouse anti-Rat, Clone: 404722, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524142
In direct ELISAs and Western blots, no cross-reactivity with recombit human (rh) MCAM, rhBCAM, or rhALCAM is observed. Reconstitute at 0.5 mg/mL in sterile PBS.CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and maligt cell types. In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development. CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
|PBS with 5% trehalose and No Preservative|
|CD146, MUC18, MCAM, Gicerin, S-endo 1 endothelial-associated antigen, cell surface glycoprotein MUC18, cell surface glycoprotein P1H12, melanoma adhesion molecule, melanoma-associated antigen A32, melanoma-associated antigen MUC18|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Mouse myeloma cell line NS0-derived recombit rat MCAM/CD146 Arg19-Lys560|
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