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MCFD2 Mouse anti-Human, Clone: 294301, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524000

Catalog No. PIMA524000


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Description

Description

In direct ELISAs, approximately 25% cross-reactivity with recombit mouse SDNSF is observed. In Western blots, no cross-reactivity with recombit mouse SDNSF is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene encodes a soluble luminal protein with 2-calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 that facilitates the transport of coagulation factors V and VIII from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment. Mutations in this gene cause combined deficiency of FV and FVIII, a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3 ft. UTR of this gene contains a transposon-like human repeat element named  ft.THE 1 ft.. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Specifications

Specifications

MCFD2
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q8NI22
F5F8D, F5F8D2, LMAN1IP, SDNSF, multiple coagulation factor deficiency protein 2, neural stem cell derived neuronal survival protein, neural stem cell-derived neuronal survival protein
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
90411
Immunohistochemistry, Western Blot
294301
Unconjugated
MCFD2
Lyophilized
MCFD2
E. coli-derived recombit human SDNSF/MCFD2 Glu27-Gln146
Protein A/G
RUO
Antibody
Monoclonal
Human
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