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MD-1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520261

Catalog No. PIPA520261


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Description

Description

A suggested positive control is Daudi cell lysate. PA5-20261 can be used with blocking peptide PEP-0376.

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Specifications

Specifications

MD-1
Polyclonal
Unconjugated
LY86
Liquid
LY86
A 15 amino acid peptide from near the center of human MD-1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O95711, O88188
RP1-80N2.1, MD-1, MMD-1, dJ80N2.1; MD-1, RP105-associated; ly-86; protein MD-1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
17084, 291359, 9450
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