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MDC1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527757

Catalog No. PIPA527757


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Description

Description

PA5-27757 targets MDC1 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27757 immunogen is recombit fragment corresponding to a region within amino acids 642 and 954 of Human MDC1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Specifications

Specifications

MDC1
Polyclonal
Unconjugated
MDC1
Liquid
MDC1
Recombit fragment corresponding to a region within amino acids 642 and 954 of Human MDC1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q14676
NFBD1, homologue to Drosophila photoreceptor protein calphotin, mediator of DNA damage checkpoint 1, mediator of DNA damage checkpoint protein 1, nuclear factor with BRCT domains 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9656
Documents
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