MilliporeSigma™ anti-MDM2, Clone: SMP14, ™ (Chemicon™)
Supplier: MilliporeSigma™ MAB3776/DEL
This antibody detects MDM2 (murine double minute-2) protein alone or in complex with p53, E2F1, and retinoblastoma protein. p53 and MDM2 function in mutual regulation; activation of p53 results in expression of MDM2 which consequently inhibits the ability of wild type p53 to stimulate expression of target genes. MDM2 is frequently overexpressed in the nuclei of soft tissue sarcomas, and to a much lesser extent in a wide variety of malignancies, such as cancer in the bladder, breast, testes, cervix, glial cells, and a range of hematological disorders.
Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation
|Synthetic peptide corresponding to residues 154-167 (CSRPSTSSRRRAISE) of human MDM2 cross-linked to KLH using glutaldehyde
|Human, Mouse, Rat
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok