ABCB4 Mouse anti-Human, Clone: P3II-26, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA135605
DescriptionThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
|Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot|
|tissue culture supernatant with 0.7% BSA and 0.1% sodium azide|
|ABC20, CD243, CLCS, GP170, MDR1, MGC163296, P-GP, PGY1|
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