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MEK1 Mouse, Unlabeled, Clone: 25/MEK1, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610122

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Catalog No. BDB610122

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MEK1 (MapK/ERK Kinase 1) is a 45kDa member of the MEK family of dual specificity kinases. MEK is activated by a variety of cellular serine/threonine kinases including c-Raf, A-Raf, c-mos, and MEK Kinase-1. Activated MEK phosphorylates MAP kinase (ERK) at threonine and tyrosine residues. This results in activation of ERK and its signaling pathway. MEK is highly specific for ERK and various MEKs preferentially phosphorylate individual ERK isoforms. MEK1 only activates ERK1 and ERK2. This specificity may result from variations in
ERK regions that are known as the phosphorylation lip and kinase backbone. MEK's localization is cytoplasmic, but mitogenic stimulation induces a mass translocation to the nucleus. Mechanisms behind this nuclear translocation remain unknown. However, MEK contains an N-terminal nuclear export signal (NES) that mediates its rapid exodus from the nucleus and restores its unstimulated cellular distribution.

Host Species: Mouse
Clone: 25
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human MEK1 aa. 2-124
Formula Weight [Chemical]: 45kDa

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Affinity Purified
Human MEK1 aa. 2-124
Cell Biology
Canine, Chicken, Frog, Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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