MEK3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528590
PA5-28590 targets MEK3 in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples. The PA5-28590 immunogen is recombit fragment corresponding to a region within amino acids 1 and 347 of Human MEK3. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
|Recombit fragment corresponding to a region within amino acids 1 and 347 of Human MEK3|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, MAP kinase kinase 3, MAPK/ERK kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, dual specificity mitogen-activated protein kinase kinase 3, stress-activated protein kinase kinase 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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