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MEK5 Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610957

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Catalog No. BDB610957


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Description

Description

The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: α (50kDa) and β (40kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins, indicating that MEK5α may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain to be identified.

Immunofluorescence, Western Blotting

Specifications

Specifications

MEK5
21
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
MAP Kinase-5
Affinity Purified
Human MEK5 aa. 13-188
150μg
Cell Biology
Primary
Canine, Human, Murine, Rat
Documents
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