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MEK5 Mouse, Unlabeled, Clone: 21, BD

Mouse Monoclonal Antibody

$226.00

Specifications

Antigen MEK5
Isotype IgG1
Immunogen Human MEK5 aa. 13-188
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610956
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BD Biosciences
610956
50μg
Each for $226.00
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BDB610957
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BD Biosciences
610957
150μg This item has been discontinued and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
Description

Description

The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn, activates ERK. MEK5, also known as MAP Kinase 5, is a 50kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing results in two MEK5 isoforms: α (50kDa) and β (40kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins, indicating that MEK5α may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain to be identified.

Immunofluorescence, Western Blotting

Specifications

Specifications

MEK5
Human MEK5 aa. 13-188
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
MAP Kinase-5
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
21
250μg/mL
Store undiluted at -20°C.
SDS
Product Certifications

For Research Use Only.

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