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MEKK2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523151

Catalog No. PIPA523151


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Description

Description

MEKK2 is a serine/threonine protein kinase, belonging to the MAP (mitogen-activated protein) kinase family. It plays an important role in activation of MAPK and preferentially activates other kinases involved in the MAP kinase signaling pathway. MEKK2 is known to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. It regulates T-cell function, controls cytokine gene expression in mast cells, mediates epidermal growth factor (EGF) receptor and fibroblast growth factor-2 (FGF-2) receptor signals,and plays a role in rheumatoid arthritis. It is also involved in LPS–TLR4 signaling, due to its phosphorylation by TLR4 ligand, LPS.
Specifications

Specifications

MEKK2
Polyclonal
Unconjugated
MAP3K2
Liquid
MAP3K2
Synthetic peptide (22 CRPALSLQETRKAKSSSPKKKQN 41) of MEKK2 protein.
Protein G
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9Y2U5
MEKK2, MEKK2B, MAP/ERK kinase kinase 2, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
10746
Documents
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