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MEL18 Mouse anti-Human, Clone: 3E4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA520275

Catalog No. PIMA520275


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Description

Description

Peptide Sequence: LTLATVPTPS EGTNTSGASE CESVSDKAPS PATLPATSSS LPSPATPSHG SPSSHGPPA

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
Specifications

Specifications

MEL18
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
P35227
PCGF2; MEL-18; polycomb group ring finger 2; RNF110; ZNF144; ring finger protein 110; zinc finger protein 144; MGC10545
Mouse
IgG2a, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
7703
ELISA, Western Blot
3E4
Unconjugated
PCGF2
Liquid
PCGF2
PCGF2 (AAH04858.1, 236 a.a. ∽ 294 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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