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mEPHX Mouse, Unlabeled, Clone: 17, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611372

Catalog No. BDB611372


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Description

Description

Microsomal epoxide hydrolase (mEPHX/mEH/EPHX) is a bifunctional membrane protein that plays a role in the metabolism of reactive epoxide intermediates and in hepatocyte uptake of bile acids. mEPHX protein and nucleic acid sequence is evolutionarily conserved in human, rats, and rabbits and mEPHX protein expression is found in the embryo and multiple organs. Cellular expression of mEPHX has been localized to both the ER and sinusoidal plasma membrane. In the ER, mEPHX is expressed in two topological orientations. The type I orientated (Ccyt/Nexo) mEPHX remains in the ER, while the type II orientated (Cexo/Ncyto) mEPHX is localized to the plasma membrane. mEPHX metabolizes DMBA to both inert metabolites and metabolites that are electrophilic and possibly carcinogenic. mEPHX null-mice have been shown to be highly resistant to DMBA-induced carcinogenesis using skin cancer bioassays. Thus, mEPHX may have protective effects, such as bile acid uptake and reactive epoxide metabolism, as well as harmful effects related to the production of carcinogens.

Immunofluorescence, Western Blotting

Specifications

Specifications

mEPHX
17
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Microsomal Epoxide Hydrolase; mEH; EPHX
Affinity Purified
Human mEPHX aa. 13-125
50μg
Cell Biology
Primary
Chicken, Frog, Human, Murine, Rat
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