Metablastin Mouse, Unlabeled, Clone: 53, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611146
The regulation of microtubule (MT) assembly is vital to cellular processes such as organelle transport, organization of the cytoplasm, and intracellular movement of cell surface receptors. MTs are composed of tubulin subunits that exist in dynamic equilibrium between free tubulin dimers and MTs. The instability of MTs is determined by the rates of growth and shrinkage of tubulin polymers and by frequencies of transitions from growth to shrinkage (catastrophes) or from shrinkage to growth (rescues). The most well known MT regulators are the
microtubule associated proteins (MAPs) which directly bind and stabilize MTs. Metablastin (stathmin) opposes MAP activity by inducing catastrophes.Metablastin is variably phosphorylated on multiple Ser residues by kinases that are regulated by the cell cycle or by external signals. Phosphorylation of metablastin inhibits its ability to destabilize MTs and, in turn, induces tubulin polymerization. Metablastin activity is turned off during the cell cycle to allow spindle formation and cell division. Thus, metablastin is thought to function to regulate the
dynamics of MT formation in response to external signals during the interphase of the cell cycle.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human Metablastin aa. 38-147
Formula Weight [Chemical]: 19kDa
Bioimaging, Immunofluorescence, Western Blotting
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Human Metablastin aa. 38-147|
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