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Metaxin Mouse, Unlabeled, Clone: 28, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611768

Catalog No. BDB611768


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Description

Description

The metaxin (Mtx) gene is closely linked to the genes for thrombospondin 3 (Thbs3), Muc1, and glucocerebrosidase (Gba) on human chromosome 1q21 and mouse chromosome 3E3-F1. Mtx is located between Thbs3 and Gba and was thus given the name “metaxin“, meaning “in between“, in Greek. Mtx and Thbs3 are positioned in a head-to-head orientation, are transcribed divergently, and share a common promoter. Mtx and Gba are positioned in a tail-to-tail orientation and are transcribed convergently. The metaxin protein is ubiquitously expressed and is 91.5% identical between human and mouse. It is rich in leucine, basic, and acidic amino acids and lacks an N-terminal signal sequence and N-glycosylation sites. Efforts to develop a mouse model for Gaucher disease involved disruption of the 3 ft. flanking region of the Gba, which is the terminal exon of Mtx. Homozygous disruption of this region resulted in the death of mice early in gestation, indicating the importance of metaxin in embryonic development. In addition, metaxin contains a putative C-terminal membrane signal anchor domain and localizes to the mitochondrial outer membrane where it is thought to function in mitochondrial import.

Host Species: Mouse
Clone: 28
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Mouse Metain aa. 66-185

Immunofluorescence, Western Blotting

Specifications

Specifications

Metaxin
28
Unconjugated
Murine
IgG1
RUO
Primary
Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Mouse Metain aa. 66-185
50μg
Cell Biology
Monoclonal
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