α-Methylacyl-CoA Racemase (AMACR) Mouse, Unlabeled, Clone: 15, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612082
α-methylacyl-CoA Racemase (AMACR) catalyzes the racemization of α-methyl-branched carboxylic acid coenzyme A thioesters. This enzymatic function is involved with biosynthesis of bile acids in the mitochondria and peroxisomes. AMACR converts pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers degraded by peroxisomal α-oxidation. Interestingly, AMACR mutations have been linked to some sensory motor neuropathies where accumulation of fatty acids and AMACR deficiencies correlate with pathogenesis. AMACR contains an N-terminal region required for mitochondrial localization, and a C-terminal peroxisomal targeting signal type 1 (PTS). AMACR mRNA is expressed preferentially in human, rat, and mouse liver and kidney, but the percentage of AMACR enzymatic activity found in the mitochondria relative to the peroxisomes differs depending on the species. Thus, AMACR is an enzyme critical for fatty acid degradation, and bile formation.
Host Species: Mouse
Species Reactivity [for Features Main]: Mouse
Immunogen: Human α-Methylacyl-CoA Racemase aa.139-229
Immunofluorescence, Western Blotting
|α-Methylacyl-CoA Racemase (AMACR)|
|Human, Murine, Rat|
|Human α-Methylacyl-CoA Racemase aa.139-229|
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