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α-Methylacyl-CoA Racemase (AMACR) Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612083

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Catalog No. BDB612083


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Description

Description

α-methylacyl-CoA Racemase (AMACR) catalyzes the racemization of α-methyl-branched carboxylic acid coenzyme A thioesters. This enzymatic function is involved with biosynthesis of bile acids in the mitochondria and peroxisomes. AMACR converts pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers degraded by peroxisomal α-oxidation. Interestingly, AMACR mutations have been linked to some sensory motor neuropathies where accumulation of fatty acids and AMACR deficiencies correlate with pathogenesis. AMACR contains an N-terminal region required for mitochondrial localization, and a C-terminal peroxisomal targeting signal type 1 (PTS). AMACR mRNA is expressed preferentially in human, rat, and mouse liver and kidney, but the percentage of AMACR enzymatic activity found in the mitochondria relative to the peroxisomes differs depending on the species. Thus, AMACR is an enzyme critical for fatty acid degradation, and bile formation.

Host Species: Mouse
Clone: 15
Isotype: IgG1
Species Reactivity [for Features Main]: Mouse
Immunogen: Human α-Methylacyl-CoA Racemase aa.139-229

Immunofluorescence, Western Blotting

Specifications

Specifications

α-Methylacyl-CoA Racemase (AMACR)
15
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Affinity Purified
Human α-Methylacyl-CoA Racemase aa.139-229
150μg
Cell Biology
Monoclonal
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