MFSD2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521049
A suggested positive control is rat lung tissue lysate. PA5-21049 can be used with blocking peptide PEP-1163.Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.
|An 18 amino acid peptide near the carboxy terminus of human MFSD2A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|mfsd2a, zgc:101615; major facilitator superfamily domain containing 2a; major facilitator superfamily domain-containing protein 2A-A|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|298504, 76574, 84879|
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