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mGluR1, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA121035

Catalog No. PIPA121035

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

PA1-21035 detects Metabotropic Glutamate Receptor 1a in Human, Mouse and Rat samples.PA1-21035 has been successfully used in Immunohistochemistry (Paraffin) and Western Blot procedures.PA1-21035 immunogen corresponds to synthetic peptide (Human) (C-terminal).
Specifications

Specifications

mGluR 1a
Polyclonal
Unconjugated
GRM1
Purified
Rabbit
IgG
500μL
4° C, do not freeze
Primary
2911
Immunohistochemistry (Paraffin), Western Blot
0.2mg/mL
PBS with 1% BSA and 0.09% sodium azide; pH 7.4
Q13255, P97772, P23385
GRM1
Synthetic peptide (Human) (C-terminal).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Murine, Rat
Documents
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