mGluR1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610965

Catalog No. BDB610965

Description

Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca²⁺ sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca²⁺; mobilization necessary for many signal transduction events.

Immunofluorescence, Western Blotting

Specifications

• Antigen: mGluR1
• Classification: Monoclonal
• Concentration: 250μg/mL
• Description: Metabotropic Glutamate Receptor-1
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

• Applications: Western Blot
• Clone: 20
• Conjugate: Unconjugated
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Rat mGluR1 aa. 1042-1160
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Mouse, Rat
• Isotype: IgG1

For Research Use Only.