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mGluR1 Rabbit anti-Rat, Polyclonal, Invitrogen™

Catalog No. 01674519
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Catalog No. Quantity
01-674-519 10 Miniblots
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Catalog No. 01-674-519 Supplier Thermo Scientific Supplier No. PA112753

Description

Rabbit Polyclonal Antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. The Glutamate Receptor, Metabotropic, 1, (mGluR1 alpha) activates phospholipase C and participates in the central action of glutamate in the central nervous system, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.

This antibody is specific for the ∽125k monomer or the ∽250k mGluR1a dimer. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen mGluR1
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Grm1
Gene Accession No. P23385
Gene Alias mGluR1a, GPRC1A, GRM1A, Human metabotropic glutamate receptor 1 alpha mRNA complete cds
Gene Symbols GRM1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the C-terminal region of mGluR1a.
Purification Method Antigen affinity chromatography
Quantity 10 Miniblots
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24414
Target Species Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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