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mGluR2/mGluR3 Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112754

Catalog No. 01-674-876

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

This antibody is specific for the ~110k monomer or the ~220k dimer of mGluR2 or mGluR3. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.
Specifications

Specifications

mGluR2/mGluR3
Polyclonal
HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P31421, P31422
MGLUR2, mGlu2, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, GPRC1B, GRM2, GRM3, GPRC1C
Rabbit
IgG
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles
Primary
24415, 24416
Immunohistochemistry (Frozen), Western Blot
Unconjugated
Grm3
Liquid
GRM2, GRM3
Synthetic peptide corresponding to the C-terminal of mGluR2 and mGluR3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Rat
Documents
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