mGluR2/mGluR3 Rabbit anti-Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112754
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.This antibody is specific for the ∽110k monomer or the ∽220k dimer of mGluR2 or mGluR3. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.
|HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|MGLUR2, mGlu2, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 3, GPRC1B, GRM2, GRM3, GPRC1C|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Frozen), Western Blot|
|Synthetic peptide corresponding to the C-terminal of mGluR2 and mGluR3.|
|Antigen affinity chromatography|
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