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mGluR1/mGluR5 Rabbit anti-Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112755

Catalog No. 01-674-877


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Description

Description

This antibody is specific for the ~125k monomer or the ~250k dimers of mGluR5 or mGluR1. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR receptor may also be critically involved in limiting the deleterious effects on excitoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA of the hippocampus (Francesconi et al., 2004).
Specifications

Specifications

mGluR1/mGluR5
Polyclonal
HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
P23385, P31424
Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5, Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1, mGlurR1a
Rabbit
IgG
10 Miniblots
-20° C, Avoid Freeze/Thaw Cycles
Primary
24414, 24418
Immunohistochemistry (Frozen), Western Blot
Unconjugated
Grm5
Liquid
GRM1, GRM5
Synthetic peptide corresponding to the C-terminal region of mGluR5 and mGluR1as.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Rat
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