mGluR1/mGluR5 Rabbit anti-Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112755
This antibody is specific for the ∽125k monomer or the ∽250k dimers of mGluR5 or mGluR1. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR receptor may also be critically involved in limiting the deleterious effects on excitoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA of the hippocampus (Francesconi et al., 2004).
|HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5|
|Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5, Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1, mGlurR1a|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Frozen), Western Blot|
|Synthetic peptide corresponding to the C-terminal region of mGluR5 and mGluR1as.|
|Antigen affinity chromatography|
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