HLA-G Mouse anti-Human, APC, Clone: MEM-G/9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119465
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.This antibody reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 was also reported. It will not cross-react with mouse.
|PBS with 0.2% BSA and 15mM sodium azide|
|4° C, store in dark, DO NOT FREEZE!|
|Recombit human HLA-G refolded with beta- 2 Microglobulin and peptide.|
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