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HLA-DR/DP/DQ Rat anti-Human, Mouse, Clone: ER-TR3, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA140077

Catalog No. 01-676-514


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Description

Description

The monoclonal antibody ER-TR3 reacts with mouse major histocompatibility complex class II (MHC class II), also know as I-A or I-E. MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.

MA1-40077 detects MHC II from mouse samples, and crossreacts with human MHC class II on tonsil.MA1-40077 has been successfully used in immunohistochemistry (frozen), immunohistochemistry (paraffin), and flow cytometry applications.The MA1-40077 immunogen is mouse MHC Class II antigen.
Specifications

Specifications

HLA-DR/DP/DQ
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P01920, P04229, P04440
MHC Class 2, MHC class II, MHC II HLA, HLA-D, HLA-DP, HLA-DQ, HLA-DR, MHC HLA-D
Rat
IgG2b
100 μg
4° C
Primary
3115, 3119, 3123
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
ER-TR3
Unconjugated
HLA-DRB1
Liquid
HLA-DPB1, HLA-DQB1, HLA-DRB1
Murine MHC Class II antigen.
Purified
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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