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MHC II HLA-DR Mouse anti-Human, Biotin, Clone: 423L, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112180

Catalog No. 01-670-895


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Description

Description

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
Specifications

Specifications

MHC II HLA-DR
Monoclonal
Biotin
CD74
Liquid
CD74
human lymphoblastoid B-cell line RPMI 8866
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
423L
PBS with 0.2% carrier protein and 0.08% sodium azide
P04233
CD74 antigen, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain, gamma chain of class II antigens, ia antigen-associated invariant chain, HLADG, DHLAG, IA-gamma
Mouse
IgG2a
100 Tests
4° C, do not freeze
Primary
972
Documents
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