LC3A Rabbit anti-Bovine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523166
DescriptionMAP1 LC3A is a structural protein and a component of both MAP1A and MAP1B microtubule-binding complexes which mediate the physical interactions between microtubules and components of the cytoskeleton. A member of the MAP1LC3 family, LC3A is known to have an ubiquitin fold at the C-terminal region and 2 helices at the N-terminal region. The posttranslational modification of LC3A precursor molecule leads to cleavage by APG4B/ATG4B, resulting in the cytosolic form, LC3-I which is further activated and modified to form the membrane-bound form, LC3-II. LC3A, a mammalian homolog of yeast Atg8, plays an essential role in autophagy, leading to bulk degradation of cytoplasmic components by the lysosomal system where it acts as an adaptor protein between microtubules and autophagosomes. Abundant expression of LC3A is seen in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
|Synthetic peptide (1 PSDRPFKQRRSFAD 15) of Microtubule-associated proteins 1A/1B light chain 3A precursor (MAP1 LC3A) protein.|
|Antigen affinity chromatography|
|Bovine, Human, Mouse, Rat, Zebrafish|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q2HJ23, Q9H492, Q91VR7, Q6XVN8|
|RP11-346K17.1, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, autophagy-related protein LC3 A, autophagy-related ubiquitin-like modifier LC3 A, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3A|
|-20° C, Avoid Freeze/Thaw Cycles|
|362245, 406466, 514547, 66734, 84557|
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