MKP2 Mouse, Unlabeled, Clone: 48, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 610850

Catalog No. BDB610850

Description

The mitogen activated protein (MAP) kinases mediate signal transduction pathways involved in cellular growth and differentiation. These MAP kinases, including ERK1 and ERK2, are activated by phosphorylation on Tyr and Thr by MEK (MAP and ERK Kinase). Regulation of the resulting physiological effects of MAP Kinase activation is affected in part by MAP Kinase phosphatases (MKPs). These phosphatases have dual specificity, dephosphorylating both the tyrosine and threonine residues on MAP kinases. MKP2, which is widely expressed in human tissues, specifically dephosphorylates activated ERKs and JNK. These phosphatases have overlapping substrate specificities for the three known families of MAP kinases - p38, ERK, and JNK. All of the known MKPs contain a highly conserved carboxyl-terminal catalytic domain flanked by two CH2 (CDC25 homology 2) domains.

Immunofluorescence, Immunoprecipitation, Western Blotting

Specifications

• Antigen: MKP2
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Rat MKP2 aa. 13-127
• Quantity: 50 μg
• Research Discipline: Cell Biology
• Target Species: Frog, Human, Mouse, Rat
• Isotype: IgG1

• Applications: Western Blot
• Clone: 48
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.