MKP2 Mouse, Unlabeled, Clone: 48, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610850
The mitogen activated protein (MAP) kinases mediate signal transduction pathways involved in cellular growth and differentiation. These MAP kinases, including ERK1 and ERK2, are activated by phosphorylation on Tyr and Thr by MEK (MAP and ERK Kinase). Regulation of the resulting physiological effects of MAP Kinase activation is affected in part by MAP Kinase phosphatases (MKPs). These phosphatases have dual specificity, dephosphorylating both the tyrosine and threonine residues on MAP kinases. MKP2, which is widely expressed in human tissues, specifically dephosphorylates activated ERKs and JNK. These phosphatases have overlapping substrate specificities for the three known families of MAP kinases - p38, ERK, and JNK. All of the known MKPs contain a highly conserved carboxyl-terminal catalytic domain flanked by two CH2 (CDC25 homology 2) domains.
Immunofluorescence, Immunoprecipitation, Western Blotting
|Rat MKP2 aa. 13-127|
|Frog, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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