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CD10 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523701

Catalog No. PIPA523701


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Description

Description

CD10 (Common Acute Lymphocytic Leukemia Antigen ,CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt ft.s, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5 ft. untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.
Specifications

Specifications

CD10
Polyclonal
PBS with 0.09% sodium azide
P08473, Q61391
CALLA, CD10, NEP, SFE, atriopeptidase, common acute lymphocytic leukemia antigen, enkephalinase, membrane metallo-endopeptidase neutral endopeptidase, enkephalinase, membrane metallo-endopeptidase neutral endopeptidase, enkephalinase, CALLA, CD10, membrane metallo-endopeptidase
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
17380, 4311
Immunohistochemistry, Western Blot
Unconjugated
MME
Liquid
MME
KLH conjugated synthetic peptide between 721-747 amino acids from the central region of human MME
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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