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MilliporeSigma anti-MMP-1, hinge region, Polyclonal,
Manufacturer: MilliporeSigma AB6002/DEL
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn2+ binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). MMP9, also known as gelatinase B, is a secreted enzyme which degrades the interstitial collagens, types I, II, and III and is produced by normal alveolar macrophages and granulocytes.
Host Species: Rabbit
Cross Reactivity: Human
Immunogen: KLH-conjugated synthetic peptide corresponding to the hinge region of human MMP-1.
|MMP-1, hinge region|
|KLH-conjugated synthetic peptide corresponding to the hinge region of human MMP-1.|
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