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MMP1 Mouse anti-Human, Clone: 3B6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112891

Catalog No. 01-674-092


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Description

Description

A suggested positive control for this product is colon, esophageal or gastric tissues.

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.
Specifications

Specifications

MMP1
Monoclonal
0.17 mg/mL
PBS with 0.08% sodium azide
P03956
MMP-1
Mouse
IgG1
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4312
Immunohistochemistry (Paraffin), Western Blot
3B6
Unconjugated
MMP1
Liquid
MMP1
Synthetic peptide derived from the C-terminus of the human MMP1.
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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