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MMP12 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527254

Catalog No. PIPA527254


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Description

Description

PA5-27254 targets MMP12 in IF, IHC (P), and WB applications and shows reactivity with Human samples. The PA5-27254 immunogen is synthetic peptide corresponding to a region within amino acids 213 and 307 of Human MMP12. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP ft.s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Specifications

Specifications

MMP12
Polyclonal
Unconjugated
MMP12
Liquid
MMP12
Synthetic peptide corresponding to a region within amino acids 213 and 307 of Human MMP12
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P39900
HME, ME, MME, MMP-12, macrophage elastase, macrophage metalloelastase, matrix metalloproteinase 12 (macrophage elastase), matrix metalloproteinase-12
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
4321
Documents
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