MMP12 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527818
PA5-27818 targets MMP12 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27818 immunogen is recombit fragment corresponding to a region within amino acids 203 and 441 of Human MMP12. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP ft.s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
|Recombit fragment corresponding to a region within amino acids 203 and 441 of Human MMP12|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|HME, ME, MME, MMP-12, macrophage elastase, macrophage metalloelastase, matrix metalloproteinase 12 (macrophage elastase), matrix metalloproteinase-12|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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