MMP13, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA125218
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.PA1-25218 detects MMP-13 from human samples.PA1-25218 has been successfully used in Western blot procedures.The PA1-25218 immunogen is a synthetic peptide corresponding to the propeptide region of human MMP-13.
|Synthetic peptide corresponding to the propeptide region of human MMP-13.|
|Antigen affinity chromatography|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.4|
|Avoid Freeze/Thaw Cycles|
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