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MMP15 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA138195

Catalog No. 01-673-902


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Description

Description

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta tissue.

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
Specifications

Specifications

MMP15
Polyclonal
PBS with 1% BSA and 0.1% sodium azide; pH 7.6
O54732, P51511
MT2-MMP, MTMMP2, SMCP-2, MMP-15, MT-MMP 2, MT2MMP, matrix metalloproteinase 15 membrane-inserted, matrix metalloproteinase-15, membrane-type matrix metalloproteinase 2, membrane-type-2 matrix metalloproteinase
Rabbit
IgG
1 mL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
17388, 4324
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
MMP15
Liquid
MMP15
Synthetic peptide from the catalytic domain of mouse MMP-15 / MT2-MMP protein
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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