MMP2 Mouse anti-Human, Clone: 4D3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112892

Catalog No. 01-674-093

Description

A suggested positive control for this product is esophageal or gastric tissues.

MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.

Specifications

• Antigen: MMP2
• Classification: Monoclonal
• Concentration: 1.48 mg/mL
• Formulation: PBS with 0.08% sodium azide
• Gene Accession No.: P08253
• Gene Alias: MMP-2
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 200 μg
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 4313

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 4D3
• Conjugate: Unconjugated
• Gene: MMP2
• Format: Liquid
• Gene Symbols: MMP2
• Immunogen: Synthetic peptide corresponding to the C-terminus of human MMP2.
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human