MMP2 Mouse anti-Human, Clone: 4D3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA112892
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.A suggested positive control for this product is esophageal or gastric tissues.
|PBS with 0.08% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide corresponding to the C-terminus of human MMP2.|
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