MMP2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129183
PA1-29183 detects MMP2 from human, rat, mouse samples. PA1-29183 has been successfully used in immunohistochemistry (paraffin tissue), and Western blot applications. The PA1-29183 immunogen was raised against amino acids 1-76 of MMP-2 of human origin.MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
|Raised against amino acids 1-76 of MMP-2 of human origin|
|Human, Mouse, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|10mM PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4|
|P08253, P33434, P33436|
|CLG4, CLG4A, MMP-II, MONA, TBE-1|
|4° C, do not freeze|
|17390, 4313, 81686|
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