MMP25 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA125309
PA1-25309 detects MMP-28 from human, mouse, and rat samples. PA1-25309 has been successfully used in Western blot procedures. The PA1-25309 immunogen is a synthetic peptide corresponding to the propeptide domain of human MMP-28. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
|Synthetic peptide corresponding to the propeptide domain of human MMP-28.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|0.01M PBS with 50% glycerol and 0.05% sodium azide; pH 7.4|
|MMP20, MMP20A, MMPL1, MT-MMP6, MT6-MMP|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|240047, 302963, 64386|
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