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MMP9 Mouse anti-Human, Clone: 4A3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112895

Catalog No. 01-674-096


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Description

Description

A suggested positive control for this product is esophageal adenocarcinoma.

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
Specifications

Specifications

MMP9
Monoclonal
1 mg/mL
PBS with 0.08% sodium azide
P14780
CLG4B, GELB, MANDP2, MMP-9
Mouse
IgG1
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
4318
Immunohistochemistry (Paraffin), Western Blot
4A3
Unconjugated
MMP9
Liquid
MMP9
Synthetic peptide derived from the n-teminus of the human MMP-9 protein and mouse myeloma Ag 8563 cells.
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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