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MMP9 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14194

Catalog No. PA14194


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Description

Description

PA1-4194 detects MMP-9 in human samples. PA1-4194 has been successfully used in Western blot procedures. The PA1-4194 immunogen is a synthetic peptide corresponding to residues W(540) R F S E G R G S R P Q G(552) of the 92 kDa human MMP-9 protein.

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
Specifications

Specifications

MMP9
Polyclonal
Unconjugated
MMP9
Liquid
MMP9
Synthetic peptide corresponding to residues W(540) R F S E G R G S R P Q G(552) of human MMP-9.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P14780
Gelatinase-B, Matrix Metalloproteinase 9, 92 kDa type IV collagenase, 92 kDa gelatinase, Gelatinase B, GELB
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
4318
Documents
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