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BMAL1 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146118

Catalog No. PIPA146118


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Description

Description

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Suggested positive control: antigen standard for ARNTL (transient overexpression lysate), reticulocyte lysate.

Circadian rhythmicity is a basic property of phylogenetically diverse organisms which range from animals and plants, to fungi. Regulation of endogenous biological clocks is regulated at the genetic level by a protein-mediated, autoregulatory feed-back loop. In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila per. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL1 transactivation complex.
Specifications

Specifications

BMAL1
Polyclonal
Unconjugated
ARNTL
Liquid
ARNTL
Bacterially expressed human MOP3 (C-terminus).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
ChIP assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
1.0 mg/mL
tris glycine with 0.02% sodium azide
O00327, Q9WTL8, Q9EPW1
BMAL1, BMAL1c, JAP3, MGC47515, MOP3, PASD3, TIC, bHLHe5
Rabbit
IgG
100 μL
4° C, do not freeze
Primary
11865, 29657, 406
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