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anti-CD42b/GPIb alpha, Clone: VM16d, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP142151

Catalog No. NBP142151


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Description

Description

CD42b/GPIb alpha Monoclonal antibody specifically detects CD42b/GPIb alpha in Human samples. It is validated for Immunocytochemistry/Immunofluorescence.
Specifications

Specifications

CD42b/GPIb alpha
VM16d
Unconjugated
0.1 mg/ml PBS with Sodium Azide
Antigen CD42b-alpha, BSS, CD42b, CD42b antigen, CD42b-alpha, glycoprotein Ib (platelet), alpha polypeptide, Glycoprotein Ibalpha, GP1B, GP-Ib alpha, GPIbA, GPIb-alpha, MGC34595, platelet glycoprotein Ib alpha chain, platelet membrane glycoprotein 1b-alpha subunit
Mouse
IgG1 Kappa
1 ml
Immunology
Primary
2811
Reconstitute with 1 ml sterile water.
Immunocytochemistry, Immunofluorescence
LYOPH
Immunocytochemistry/Immunofluorescence 1:10-1:2000
Precipitation
GP1BA
The antibody reacts with the CD42b antigen.
Ammonium sulfate precipitation
RUO
Store at 4C. Do not freeze.
Monoclonal
The monoclonal antibody is directed against the CD42b antigen, platelet glycoprotein GPIb, that serves as a receptor for von Willebrand factor and as a high affinity thrombin receptor. The antigen is expressed on human platelets and megakaryocytes. The antigen is absent or present in very low levels on platelets of patients with the Bernard-Soulier syndrome. VM16d inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F (ab') 2 and F (ab') fragments are equally effective as whole intact antibodies. The VM16d-epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain. VM16d does not effect platelet interaction with von Willebrand factor, leading to the conclu-sion that the antibody reacts with or nearby the thrombin receptor site.
Human
Documents
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