anti-CD42b/GPIb alpha, Clone: VM16d, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP142151
DescriptionCD42b/GPIb alpha Monoclonal antibody specifically detects CD42b/GPIb alpha in Human samples. It is validated for Immunocytochemistry/Immunofluorescence.
|0.1 mg/ml PBS with Sodium Azide|
|Antigen CD42b-alpha, BSS, CD42b, CD42b antigen, CD42b-alpha, glycoprotein Ib (platelet), alpha polypeptide, Glycoprotein Ibalpha, GP1B, GP-Ib alpha, GPIbA, GPIb-alpha, MGC34595, platelet glycoprotein Ib alpha chain, platelet membrane glycoprotein 1b-alpha subunit|
|Reconstitute with 1 ml sterile water.|
|Immunocytochemistry, Immunofluorescence, In vitro Assay|
|Immunocytochemistry/Immunofluorescence 1:10-1:2000, In vivo assay|
|The antibody reacts with the CD42b antigen.|
|Ammonium sulfate precipitation|
|Store at 4C. Do not freeze.|
|The monoclonal antibody is directed against the CD42b antigen, platelet glycoprotein GPIb, that serves as a receptor for von Willebrand factor and as a high affinity thrombin receptor. The antigen is expressed on human platelets and megakaryocytes. The antigen is absent or present in very low levels on platelets of patients with the Bernard-Soulier syndrome. VM16d inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F (ab') 2 and F (ab') fragments are equally effective as whole intact antibodies. The VM16d-epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain. VM16d does not effect platelet interaction with von Willebrand factor, leading to the conclu-sion that the antibody reacts with or nearby the thrombin receptor site.|
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